复方甘菊利多卡因凝胶在慢性牙周炎辅助治疗中的疗效研究

The efficacy of compound chamomile lidocaine gel in the adjunctive treatment of chronic periodontitis

目的:研究复方甘菊利多卡因凝胶在慢性牙周炎辅助治疗中的疗效。方法:选取中、重度牙周炎患者60例,牙周基础治疗后随机分为辅助治疗组和对照组(无辅助治疗),每组30例。用分口设计法将辅助治疗组患者两侧随机分为甘菊组和米诺组,基础治疗后于牙周袋内分别置入复方甘菊利多卡因凝胶和盐酸米诺环素软膏。记录治疗前、治疗后6、12周临床牙周指标、采集龈下菌斑,PCR法检测致病菌Pg和Pi。结果:(1)甘菊组与米诺组中致病菌的检出率及临床牙周指标在治疗后均低于治疗前(P<0.05),组间无差异(P>0.05);(2)甘菊组和米诺组均优于对照组(P<0.05)。结论:复方甘菊利多卡因凝胶可作为慢性牙周炎辅助治疗的局部用药,与盐酸米诺环素软膏有相同的抑菌作用和疗效。

Objective:To study the effects of compound chamomile lidocaine gel(CCLG)in the local adjunctive treatment of chronic periodontitis.Methods:60 patients with moderate or sever periodontitis after periodontal basic treatment were randomly divided into adjunctive group and control group(n=30).The patients in adjunctive group were divided into CCLG and minocycline hydrochloride ointment(MINO)groups by split-mouth design.After periodontal basic treatment,CCLG and MINO were delivered into the periodontal pocket of left side and right side respectively of the subjects.Clinical periodontal indexes were measure before and 6 weeks and 12 weeks after treatment,and subgingival plaque was collected.The detection rate of periodontal pathogenic bacteria Pg and Pi were detected by PCR.Results:(1)The detection rate of periodontal pathogenic bacteria and clinical periodontal indexes in CCLG gruop and MINO group was lower after treatment than before(P<0.05),there was no difference between the 2 groups(P>0.05);(2)The effects of CCLG group and MINO group were superior than those of the control group(P<0.05).Conclusion:Compound chamomile lidocaine gel is as effective as minocycline hydrochloride in the adjuctive treatment of chronic periodontitis.