血栓心脉宁片抗动脉粥样硬化的网络药理学分析

Analysis of Xueshuan Xinmaining Tablets for Anti-atherosclerosis Based on Network Pharmacology

目的通过网络药理学方法探讨血栓心脉宁片抗动脉粥样硬化的可能作用机制。方法采用BATMAN-TCM平台对血栓心脉宁片进行网络药理学分析。结果血栓心脉宁片2201个潜在靶标分子(score≥20分)的功能分布显示,在94个功能条目显著富集,如信号传导活性、脂质代谢、细胞增殖等。运用京都基因与基因组百科全书(KEGG)通路富集分析潜在靶标分子,发现靶标分子KEGG生物学通路显著富集在AMPK信号通路、MAPK信号通路、cGMP-PKG信号通路等78个通路,涉及血管功能的调节、脂质运输与降解、糖脂代谢等过程。通过靶标基因的疾病条目富集分析发现,血栓心脉宁片对心律失常、心力衰竭、冠状动脉粥样硬化性心脏病等疾病有一定治疗作用。结论通过网络药理学预测血栓心脉宁片可能通过调节糖脂代谢、信号转导通路等环节发挥抗动脉粥样硬化作用。

Objective To explore the anti-atherosclerosis mechanism of Xueshuan Xinmaining Tablets based on network pharmacology.Methods The network pharmacology of Xueshuan Xinmaining Tablets was analyzed by Batman-TCM platform.Results The functional distribution of 2201 potential target molecules(score≥20)in Xueshuang Xinmaining Tablets,and 94 functional items,such as signal translocation activity,lipid metabolism,cell proliferation were analysed.The Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway were used for enrichment analysis of potential target molecules,and found that the KEGG biological pathway of target molecules were significantly enriched in 78 pathways,including AMPK,MAPK,and cGMP-PKG signaling pathways,which involved the regulation of vascular function,lipid transport and degradation,and glucose and lipid metabolism.Through the enrichment analysis of disease items of target genes,it was found that Xueshuan Xinmaining Tablet had certain therapeutic effects on arrhythmia,heart ailure,atherosclerotic cardiovascular disease and other diseases.Conclusion Through network pharmacology,Xueshuan Xinmaining Tablet might play an anti-atherosclerosis role by regulating glucose,lipid metabolism and signal transduction pathway.