外周血miR-210表达及血清VEGF含量与脑梗死再发的相关性

Correlation between the expression of miR-210 in peripheral blood,the content of VEGF in serum and recurrence of cerebral infarction

目的研究外周血miR-210表达及血清血管内皮生长因子(VEGF)含量与脑梗死再发的相关性。方法选择2017年3月至2019年3月期间本院收治的急性脑梗死患者,随访发病后1年是否再发脑梗死并分为再发组和未再发组,比较两组外周血miR-210表达、血清VEGF含量及临床资料的差异,采用ROC曲线分析miR-210及VEGF对脑梗死再发的预测价值,采用COX回归模型分析脑梗死再发的影响因素。结果与未再发组比较,再发组患者的外周血miR-210表达水平及血清VEGF含量明显降低,差异均有统计学意义(P<0.05);经ROC曲线分析,外周血miR-210表达水平、血清VEGF含量对脑梗死再发具有预测价值(P<0.05);经COX回归分析,外周血miR-210表达水平及血清VEGF含量是脑梗死再发的影响因素(P<0.05)。结论急性脑梗死患者外周血miR-210表达及血清VEGF含量降低与脑梗死再发有关。

Objective To study the correlation between the expression of miR-210 in peripheral blood,the content of vascular endothelial growth factor(VEGF)in serum and the recurrence of cerebral infarction. Methods Patients with acute cerebral infarction admitted to our hospital from March 2017 to March2019 were selected. They were divided into recurrent group and non recurrent group according to the recurrence of cerebral infarction one year after the onset. The differences of miR-210,VEGF and clinical data between the two groups were compared. ROC curve was used to analyze the predictive value of miR-210,VEGF on recurrence of cerebral infarction,and COX regression model was used to analyze the influencing factors of recurrent cerebral infarction. Results Compared with the non recurrence group,the expression of miR-210 in peripheral blood,the content of VEGF in serum were significantly lower(P<0.05);ROC curve analysis showed that the expression level of mir-210 in peripheral blood and the content of VEGF in serum had predictive value for the recurrence of cerebral infarction(P<0.05);COX regression analysis showed that the expression level of mir-210 in peripheral blood and the content of VEGF in serum were the influencing factors for the recurrence of cerebral infarction(P<0.05). Conclusion the decreased expression of miR-210 in peripheral blood and the content of VEGF in serum of patients with acute cerebral infarction are related to the recurrence of cerebral infarction.