呋喃脂肪酸的来源与功能研究进展

Advance in the resource and function of furan fatty acids

呋喃脂肪酸是一组以呋喃环为主体的特殊脂肪酸,多存在于微生物、植物及鱼类中。研究表明,呋喃脂肪酸可以有效地清除活性氧自由基,并且减缓氧化胁迫诱导的损伤。然而,呋喃脂肪酸代谢产物3-羧基-4-甲基-5-丙基-2-呋喃丙酸对糖尿病及慢性肾病病情进展的作用仍存在争议。进一步深入研究呋喃脂肪酸的结构与生理功能,是目前呋喃脂肪酸研究的重要方向。对呋喃脂肪酸的来源、合成代谢及对人体的生理效应研究进展进行综述,为呋喃脂肪酸及其产物的后续研究提供参考。

As a class of special fatty acids with a furan moiety in the central part,furan fatty acids( F-acids) are mainly found in microorganisms,plants and fish. Recent studies have showed that F-acids can effectively scavenge reactive oxygen free radicals,and alleviate oxidative stress-induced damage.However,the relationships of one metabolite of F-acids,3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid( CMPF),with diabetes and chronic kidney disease remain controversial. Further investigation on the structure and physiological function of F-acids is a critical direction for the study of F-acids. The research progress on the source,synthesis and physiological functions of furan fatty acids were summarized to provide reference for the further research on F-acids and their products.