摘要
华法林是临床上应用广泛的香豆素类口服抗凝药,主要用于预防和治疗多种血管栓塞类疾病。华法林主要通过抑制维生素K的循环利用,从而产生药理作用,并主要由细胞色素P450酶代谢后,经肾排出体外。但华法林治疗窗较窄,个体及种族差异较大,药物不良反应严重,易受人体的多种因素影响,其中遗传多态性居于主要地位。本文将着重从遗传多态性方面入手,阐述遗传因素对华法林临床用量的影响,以期为临床制定华法林的个体化给药方案提供参考。
Warfarin is a widely used coumarin oral anticoagulant in clinical practice,which is mainly used to prevent and treat various vascular embolism diseases.Warfarin has pharmacological effects mainly by inhibiting the recycling of vitamin K,and is mainly metabolized by cytochrome P450 enzyme and excreted by kidney.However,warfarin has a narrow treatment window with large individual and ethnic variabilities that exerted serious adverse reactions.Moreover,warfarin is susceptible to various factors in the human body.Among them,genetic polymorphism occupied the main position.This article will focus on the genetic polymorphism to elaborate the influence of genetic factors on the clinical dosage of warfarin,in order to provide a reference for the clinical individualized medication of warfarin.
作者
左旭锐
吕春晓
黄宇虹
邹澍宣
ZUO Xu-rui;LüChun-xiao;HUANG Yu-hong;ZOU Shu-xuan(Department of Clinical Pharmacology,The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300250,China;Department of Clinical Training,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2021年第7期925-928,共4页
The Chinese Journal of Clinical Pharmacology
基金
国家重大科技专项资助项目(2018ZX09734-002)
国家自然科学基金青年基金资助项目(81803930)。
关键词
华法林
遗传多态性
个体化用药
warfarin
genetic polymorphism
individualized medication
