益生菌对自身免疫病的作用及机制研究现状

Research progress and mechanism of probiotics on autoimmune diseases

自身免疫病是机体免疫功能紊乱而导致组织器官受损的一类疾病,包括类风湿关节炎、系统性红斑狼疮、多发性硬化症、自身免疫性肝炎等。糖皮质激素及免疫抑制剂是治疗自身免疫病的常用药物,但长期使用会产生代谢紊乱、免疫低下、继发感染等副作用。随着肠道菌群与自身免疫病相关研究的进展,益生菌干预自身免疫病成为一大研究热点。研究证实,益生菌缓解自身免疫病安全有效,有望成为辅助疗法甚至替代疗法。本文就益生菌缓解类风湿关节炎、系统性红斑狼疮、多发性硬化症、自身免疫性肝炎等的作用及相关机制进行综述。

Autoimmune diseases are disorder of immune function leading to damage of tissues and organs, including rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, autoimmune hepatitis and so on. Glucocorticoids and immunosuppressants are commonly used for the treatment of autoimmune diseases, but usually carry a risk of serious side effects such as metabolic disorders, immunodeficiency and secondary infections. With the progress of research on intestinal flora and autoimmune diseases, the treatment of probiotics has become a research focus in autoimmune diseases. Studies have confirmed that the treatment of autoimmune diseases with probiotics is safe and effective, which is expected to become assisted therapy or even alternative therapy. This review discussed the effects and related mechanisms of probiotics in relieving rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis and autoimmune hepatitis.