JAK-STAT通路在糖尿病肾病中的作用及中药干预的研究进展

Research progress on JAK-STAT pathway in diabetic nephropathy and intervention effect of traditional Chinese medicine

糖尿病肾病(diabetic nephropathy,DN)是糖尿病的主要微血管并发症之一,也是导致终末期肾病的重要原因。多种因素共同参与DN的发生,其中Janus激酶/信号转导与转录激活子(Janus kinase/signal transducer and activator of transcription,JAK-STAT)可以通过促进炎症因子的表达、诱导炎症细胞活化等途径导致DN肾组织炎症性损伤,在DN的发生发展中起着重要作用。大量文献研究显示,中药在防治DN中具有明显的优势。某些中药或中药提取物能够调节JAK-STAT信号通路,从而改善DN肾组织的炎症性损伤,进而发挥肾脏保护作用。将近年来关于JAK-STAT通路在DN中的研究进展及中药的干预作用现状进行综述,以期为其深入研究提供参考。

Diabetic nephropathy(DN) is one of the main microvascular complications of diabetes, and also an important cause of endstage renal disease. Many factors are involved in the occurrence of DN. Among them, JAK-STAT can cause renal inflammatory injury by promoting the expression of inflammatory factors and inducing the activation of inflammatory cells, and it plays an important role in the occurrence and development of DN. A large number of literature studies have shown that traditional Chinese medicine had obvious advantages in the prevention and treatment of DN. Some traditional Chinese medicine or their extracts can regulate JAK-STAT signaling pathway, thereby improving the renal tissue inflammatory injure of DN, and then exerting a renal protective effect. In this paper, the research progress of JAK-STAT signaling pathway in DN and the intervention effect of traditional Chinese medicine in recent years is reviewed, in order to provide a reference for its in-depth study.