3,4-裂环羽扇豆烷型三萜化合物及其生物活性研究进展

Advance in 3,4-seco-lupane type triterpenoids and their bioactivity

3,4-裂环羽扇豆烷型三萜是五环三萜类化合物,在五加属植物中含量较为丰富。药理学研究表明该类成分具有广泛的生物活性,主要包括抗炎、抗菌、抗肿瘤等作用,具有潜在开发应用价值。通过查阅国内外相关文献报道,从化学结构特征、植物来源和生物活性等方面对天然来源的3,4-裂环羽扇豆烷型三萜类化合物的研究进展进行综述,以期为此类化合物的进一步研究及五加属植物药用资源的合理应用与开发提供参考依据。

3,4-Seco-lupane type triterpenoids are pentacyclic triterpenoids,which are abundant in the plants of Acanthopanax genus.Pharmacological studies have shown that 3,4-seco-lupane type triterpenoids have a wide range of biological activities,such as anti-inflammatory,antibacterial,and anti-tumor activities.3,4-seco-Lupane type triterpenoids have potential development and application value.By referring to relevant domestic and foreign literature reports,the research progress of 3,4-seco-lupane type triterpenoids is reviewed in terms of chemical structure,plant origin and biological activities.It provides a reference for further study of 3,4-seco-lupane type triterpenoids and the development of medicinal resources of Acanthopanax.