归脾汤加减联合右佐匹克隆对失眠患者PSQI评分及夜间觉醒次数的影响

Effects of Modified Guipi Decoction and Eszopiclone on PSQI Score and Numbers of Awakening at Night in Insomnia Patients

目的:探讨归脾汤加减联合右佐匹克隆对失眠患者匹茨堡睡眠质量指数量表(PSQI)评分及夜间觉醒次数的影响。方法:选取2019年1-12月于本院接受治疗的85例失眠患者为研究对象,依据随机数字表法将其分为对照组(42例)与观察组(43例)。对照组采用右佐匹克隆治疗,观察组在对照组基础上联合归脾汤加减治疗,两组均连续治疗4周。比较两组治疗前后PSQI评分、夜间觉醒次数和治疗期间不良反应发生情况。结果:观察组临床总有效率为95.35%,高于对照组的78.57%,差异有统计学意义(P<0.05)。治疗4周后,两组PSQI各维度评分均低于治疗前,且观察组各维度评分均较对照组低,差异均有统计学意义(P<0.05)。治疗4周后,两组夜间觉醒次数均少于治疗前,且观察组较对照组少,差异均有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:归脾汤加减与右佐匹克隆联合治疗失眠患者效果显著,可有效提升患者睡眠质量,减少夜间觉醒次数,且不会增加不良反应。

Objective:To investigate the effect of Guipi Decoction combined with Eszopiclone on the Pittsburgh sleep quality index(PSQI)score and the number of night awakening in patients with insomnia.Method:A total of 85 patients with insomnia who were treated in our hospital from January to December 2019 were selected as the research object,they were divided into control group(42 cases)and observation group(43 cases)according to random number table method.The control group was treated with Eszopiclone,the observation group was combined with Guipi Decoction on the basis of the control group,both groups were treated continuously for 4 weeks.The PSQI score and the numbers of awakening at night before and after treatment were observed in the two groups,the occurrence of adverse reactions during the treatment was compared between the two groups.Result:The total effective rate of the observation group was 95.35%,higher than 78.57%of the control group,the difference was statistically significant(P<0.05).After 4 weeks of treatment,scores of all dimensions of PSQI in both groups were lower than those before treatment,scores of all dimensions in the observation group were lower than those in the control group,the differences were statistical significance(P<0.05).After 4 weeks of treatment,the numbers of awakening at night in both groups were less than those before treatment,the observation group was less than that of the control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The combination of Guipi Decoction and Dezopiclone in the treatment of insomnia patients has a significant effect,which can effectively improve the sleep quality of patients,reduce the numbers of awakening at night,will not increase adverse reactions.