达美康与二甲双胍对2型糖尿病临床治疗效果及生活质量的影响

The Effect of Gliclazide and Metformin on Clinical Treatment Effect and Quality of Life of Type 2 Diabetes

目的探讨对2型糖尿病患者采用达美康与二甲双胍联合治疗的临床效果以及对改善患者生活质量的作用。方法选择该科2018年1月—2019年12月诊治2型糖尿病患者82例,按照治疗方案不同分为单采用达美康治疗对照组(n=41)与采用二甲双胍联合达美康治疗实验组(n=41),对比临床疗效、治疗前后血糖指标(空腹血糖、餐后2 h血糖)以及治疗前后生活质量。结果实验组治疗4月后总好转率为95.12%(39/41),高于对照组80.49%(33/41),差异有统计学意义(χ^(2)=4.100,P<0.05);实验组后治疗空腹血糖(5.40±1.04)mmol/L、餐后2 h血糖(9.11±0.94)mmol/L,低于对照组(7.28±1.16)、(11.17±1.08)mmol/L,差异有统计学意义(t=7.727、9.213,P<0.05)。实验组治疗后DMQLS评分为(40.84±1.79)分,高于对照组(34.15±1.37)分,差异有统计学意义(t=19.004,P<0.05)。结论对给予2型糖尿病患者达美康、二甲双胍联合疗法可提高治疗效果,有利于改善血糖指标以及患者的生活质量,对改善患者预后有显著价值,值得在临床中广泛应用。

Objective To investigate the clinical effect of combined treatment with Damecan and metformin in patients with type 2 diabetes and its effect on improving the quality of life of patients.Methods From January 2018 to December 2019,82 patients with type 2 diabetes were diagnosed and treated in the department.According to different treatment plans,they were divided into a control group treated with Glicalzide alone(n=41)and an experimental group treated with metformin combined with Gliclazide(n=41).The clinical efficacy,blood glucose indicators before and after treatment(fasting blood glucose,2 h blood glucose after meal)and quality of life before and after treatment were compared.Results The total improvement rate of the experimental group after 4 months of treatment was 95.12%(39/41),which was higher than 80.49%(33/41)of the control group,the difference was statistically significant(χ^(2)=4.100,P<0.05).The experimental group treated fasting blood glucose(5.40±1.04)mmol/L,2 h postprandial blood glucose(9.11±0.94)mmol/L after treatment,which were lower than the control group(7.28±1.16)mmol/L,(11.17±1.08)mmol/L,the difference was statistically significant(t=7.727,9.213,P<0.05).The DMQLS score of the experimental group after treatment was(40.84±1.79)points,which was higher than the control group(34.15±1.37)points,the difference was statistically significant(t=19.004,P<0.05).Conclusion The combination therapy of gliclazide and metformin for type 2 diabetes patients can improve the therapeutic effect,help improve the blood glucose index and the patient’s quality of life,have significant value in improving the prognosis of patients,and is worthy of being widely used in clinical practice.