针刺治疗顽固性呃逆的Meta分析

Meta-analysis of Acupuncture Treatment for Intractable Hiccup

目的:系统评价针刺治疗顽固性呃逆的有效性及安全性。方法:检索中国生物医学文献数据库(CBM),国家知识基础设施数据库(简称中国知网,China National Knowledge Infrastructure,CNKI),中文科技期刊数据库(简称维普资讯,Chinese Citation Database,CCD),中国学术期刊数据库(简称万方数据库,China Science Periodical Database,CSPD)以及Pubmed,收集针灸治疗顽固性呃逆的随机对照临床试验研究文献,检索年限从建库至2019年6月1日。对最终纳入的文献进行风险偏倚评估后,用RevMan5.3软件进行Meta分析。结果:纳入12个研究,共计1383例患者,Meta分析显示:针刺组总有效率优于西药常规观察组[RR=1.26,95%CI为(1.21~1.32),P<0.00001];痊愈率优于西药常规观察组[RR=1.51,95%CI为(1.35~1.70),P<0.00001];不良反应率低于对照组(RR=0.11,95%CI为0.03~0.34,P=0.0002)。结论:针刺治疗顽固性呃逆效果显著,且安全性较高。

Objective:To systematically evaluate the efficacy and safety of acupuncture in the treatment of intractable hiccups.Methods:CNKI,Wanfang Data Knowledge Service Platform,VIP Journal Resource Integration Service Platform,Pubmed were retrieved and randomized controlled clinical trial research literature on acupuncture treatment of intractable hiccups were collected.The search period was set from the establishment of the databases to June 1,2019.Meta-analysis was performed by using RevMan5.3 software after risk-biased evaluation of the final included literature.Results:A total of 12 RCT study were included in the study,with 1383 patients.The Meta results showed that the total effective rate of the acupuncture group was better than that of the Western medicine group[RR=1.26,95%CI(1.21~1.32),P<0.00001].The curative rate was superior to the Western medicine routine treatment group[RR=1.51,95%CI(1.35~1.70),P<0.00001];the adverse reaction rate was lower than the control group[RR=0.11,95%CI(0.03~0.34),P=0.0002].Conclusion:The effect of acupuncture treatment on intractable hiccup was significant and the safety of acupuncture treatment was higher.