丁苯酞氯化钠注射液治疗超静脉溶栓时间窗急性脑梗死的疗效观察

Therapeutic effect of butylphthalide sodium chloride injection on patients with acute cerebral infarction beyond the time window of intravenous thrombolysis

目的探讨丁苯酞氯化钠注射液治疗超静脉溶栓时间窗急性脑梗死的疗效。方法回顾性分析2018-06—2019-11武汉市武昌医院治疗的超静脉溶栓时间窗急性脑梗死住院患者110例,随机分为对照组和观察组,2组患者均接受抗血小板聚集、降脂及保护神经等对症支持治疗,观察组患者加用丁苯酞氯化钠注射液治疗14 d。观察治疗前后2组患者血清高敏C反应蛋白(hs-CRP)、脂联素(APN)水平、NIHSS评分的变化,比较2组患者90 d mRS评分变化。结果丁苯酞氯化钠注射液治疗14 d后,观察组较对照组血清hs-CRP降低、APN水平升高、NIHSS评分降低,差异均有统计学意义(P<0.05)。90 d后观察组mRS评分低于对照组,差异有统计学意义(P<0.05)。结论丁苯酞氯化钠注射液治疗超时间窗急性脑梗死患者,能够促进受损神经功能恢复,改善患者远期临床预后。

Objective To investigate the effect of butylphthalide sodium chloride injection in the treatment of acute cerebral infarction beyond the time window of intravenous thrombolysis.Methods Totally 110 patients with acute cerebral infarction in our hospital from June 2018 to November 2019 were randomly divided into control group and observation group,patients in the two groups were treated with antiplatelet aggregation,lipid lowering and neuroprotection.Patients in the observation group were treated with butylphthalide sodium chloride injection for 14 days.The changes of serum high-sensitivity C-reactive protein(hs-CRP),Adipo⁃nectin(APN)and NIHSS scores were compared between the two groups before and after treatment.Modified Rankin scale(mRS)scores were compared between the two groups after 90 days.Results After 14 days of treatment with butylphthalide sodium chloride injection,the levels of hs-CRP,APN and NIHSS in the observation group were significantly lower than those in the control group.After 90 days,the mRS score of the observation group was lower than that of the control group significantly.Conclusion Bu⁃tylphthalide sodium chloride injection can promote the recovery of neurological function and improve the long-term clinical prognosis in patients with acute cerebral infarction.