疫苗增强性疾病风险探讨

Discuss about Vaccine Enhancement of Disease

目的对疫苗增强性风险进行探讨,为新型冠状病毒疫苗上市后安全性监测提供参考。方法通过检索、整理国内外关于病毒类疫苗与疫苗增强性疾病的研究成果,关注新型冠状病毒疫苗潜在的安全性问题。结果与结论2020年新型冠状病毒引发的疫情蔓延全球,由于目前尚无针对新型冠状病毒的特效治疗药物,新型冠状病毒疫苗的研发己成为全球关注的热点。疫苗增强性疾病是疫苗研发和上市后安全性监测中普遍关注的一个问题。根据目前已有的研究成果,疫苗增强性疾病风险成为新型冠状病毒疫苗的不确定性因素,需要在今后的研究和使用中认真分析和评价。

Vaccine Enhancement of Disease was discussed in this paper,in order to provide information for postmarketing surveillance of SARS-CoV-2 vaccines.Methods The documents and research findings about virus vaccines and vaccine enhancement of disease(VED)were collected to analyze the safety of SARS-CoV-2 vaccines.Results and Conclusion The epidemic caused by SARS-CoV-2 has been spreading globally since 2020.As no wonder drugs are currently available,vaccine development is becoming a hot topic worldwide.Due to its uncertainty,VED is one of the common concerns during vaccine development and post-marketing surveilance should be carefully assessed in the future.