细辛挥发油的化学成分及其药理和毒理现代研究进展

Research Progress in Chemical Constituents,Pharmacology and Toxicology of Volatile Oil in Asarum

中药细辛的临床应用十分广泛,挥发油类物质作为其主要有效成分,具有麻醉、解热、镇痛、抗炎等药理作用,但是细辛挥发油也普遍被认为是其毒副作用的物质基础,使用不当可能会导致严重的毒性反应。通过查阅近10年文献,就细辛挥发油中主要成分及其药理和毒理作用的现代研究进行整理、分析和归纳,认为有必要对细辛挥发油中主要成分进行针对性的药效和毒性研究,以期为细辛合理和有效应用、确保临床用药安全提供参考。

The clinical application of Asarum in traditional Chinese medicine is very extensive.Volatile oil,as a main active ingredient of Asarum,has a series of pharmacological effects such as anesthesia,antipyretic action,analgesia,anti-inflammation.However,Asarum volatile oil is also generally considered the material basis of its toxic and side effects,and improper use may lead to serious toxic reactions.In this study,the main components of Asarum volatile oil and recent research on their pharmacological and toxicological effects were categorized,analyzed and summarized by reviewing literature published over the past ten years.There is the need to carry out targeted pharmacodynamic and toxicological research on the main components of Asarum volatile oil in order to provide reference for the rational and effective application of Asarum and ensure the safety of clinical medication.