维生素D水平与脓毒症免疫功能相关性的临床研究

Correlation between immune function and vitamin D level in sepsis

目的探讨脓毒症患者血清维生素D(vitamin D,VD)水平与免疫功能的关系。方法采用病例对照研究方法,以福建中医药大学附属第二人民医院2018年12月至2020年12月收治的30例脓毒症患者作为脓毒症组,选择20例本院体检中心同期健康体检人群作为对照组。同时根据VD水平将脓毒症组分为VD严重缺乏组(16例)、VD缺乏组(10例)和VD正常组(4例)。分析VD水平与CD4、降钙素原(procalcitonin,PCT)的相关性。结果脓毒症患者中VD严重缺乏者占53.3%(16/30),VD缺乏者占33.3%(10/30),VD正常者仅占13.3%(4/30),与对照组比较,脓毒症组VD水平、CD4水平显著降低,差异有统计学意义(P<0.05)。与VD正常组相比,VD严重缺乏组和VD缺乏组CD4水平显著降低,差异有统计学意义;与VD正常组相比,VD严重缺乏组和VD缺乏组PCT水平显著升高,差异有统计学意义(P<0.05)。结论 VD水平与脓毒症患者的免疫功能具有一定的相关性。

Objective To investigate the relationship between serum vitamin D(VD)level and immune function in patients with sepsis.Methods A case-control study was designed to collect data of patients from the Second People’s Hospital Affiliated to Fujian University of Chinese Medicine between December 2018 and December 2020.They were divided to sepsis patients as the sepsis group(n=30)and non-sepsis patients with healthy physical examination report as the control group(n=20).According to the level of VD,the sepsis group was further divided into severe VD deficiency group(n=16),VD deficiency group(n=10)and normal VD group(n=4).The correlation The correlation between VD level and CD4,as well as the correlation between VD level and procalcitonin(PCT)were analyzed.Results There were 53.3%(16/30)patients with severe VD deficiency,33.3%(10/30)patients with VD deficiency,and only 13.3%(4/30)patients with normal VD.Compared with the control group,the levels of VD and CD4 in the sepsis group were significantly decreased,and the differences were statistically significant(P<0.05).Compared with the normal VD group,CD4 levels in the severe VD deficiency group and the VD deficiency group were significantly decreased,and the difference was statistically significant(P<0.05).Compared with normal VD group,PCT level was significantly higher in severe VD deficiency group and VD deficiency group,and the difference was statistically significant(P<0.05).Conclusion VD level can affect the immune function of patients with sepsis.