新疆哈萨克族代谢综合征与血清镁水平的关联

The association between metabolic syndrome and serum magnesium level in Xinjiang Kazakh

目的为探索新疆哈萨克族代谢综合征及其组分与血清镁元素的关联。方法采用病例对照研究探索新疆哈萨克族代谢综合征与血清镁的关系,比较不同水平血清镁组MS患者构成比的差异,采用广义相加模型分析MS及其组分与血清镁的关联。结果病例组血清镁(0.81±0.13 mmol·L^(-1))低于对照组(0.84±0.09 mmol·L^(-1));低血镁组和高血镁组MS患者构成比均高于正常血镁组;校正相关因素后低血镁和高血镁MS患病风险OR值分别为(3.15,95%CI:2.04,4.85)、(1.87,95%CI:1.14,3.07);低血镁和高血镁均可增加高甘油三酯血症、低HDL-C血症和中心性肥胖的风险。结论低血镁和高血镁均可增加新疆哈萨克族MS及组分的患病风险。

Objective To explore the association between metabolic syndrome and serum magnesium level in Xinjiang Kazakh. Methods Case-control study was used to explore the relationship between serum magnesium and metabolic syndrome of kazak ethnic group in Xinjiang. We compare the difference in composition ratio of MS patients with different serum magnesium levels,and to analyze the correlation between MS and serum magnesium with generalized additive model. Results The serum magnesium(0. 81± 0. 13 mmol·L^(-1)) in the case group was lower than that in the control group( 0. 84±0. 09 mmol·L^(-1)). The composition ratio of MS patients in hypermagnesemia group and hypomagnesemia group was higher than that in Mg-normal group. After adjusting for relevant factors,the OR values of MS for hypermagnesemia group and hypomagnesemia group were(3. 15,95% CI: 2. 04,4. 85) and(1. 87,95% CI: 1. 14,3. 07),respectively. Both hypermagnesemia and hypomagnesemia increase the risk of MS,low HDL-C and central obesity. Conclusion Both hypermagnesemia and hypomagnesemia increase may increase the risk of MS and its components in Kazaks.