伏硫西汀与文拉法辛治疗抑郁症临床研究

Clinical study of vortioxetine and venlafaxine in the treatment of depression

目的探讨伏硫西汀治疗抑郁症的临床疗效及安全性。方法将113例抑郁症患者按随机数字表法分为伏硫西汀组59例和文拉法辛组54例。伏硫西汀组给予伏硫西汀治疗,文拉法辛组予以文拉法辛治疗,观察8周。于治疗前后采用临床疗效总评量表评定临床疗效,汉密顿抑郁量表总分及认知障碍因子评定疾病严重程度及认知功能,副反应量表评定不良反应。结果两组治疗总有效率比较差异无统计学意义(P>0.05)。治疗2周末起两组汉密顿抑郁量表总分均较治疗前显著下降(P<0.01),同期两组间比较差异无统计学意义(P>0.05);治疗8周末伏硫西汀组认知障碍因子分较治疗前显著下降(P<0.01),文拉法辛组则无显著变化(P>0.05),伏硫西汀组显著低于文拉法辛组(P<0.05)。两组均未出现严重不良反应,不良反应发生率比较差异无统计学意义(P>0.05)。结论伏硫西汀与文拉法辛治疗抑郁症起效快,疗效确切,安全性高,但伏硫西汀对认知功能的改善优于文拉法辛。

Objective To explore the clinical efficacy and safety of vortioxetine in the treatment of depression.Methods A total of 113 patients with depression were randomly divided into the vortioxetine group(n=59)and the venlafaxine group(n=54).The vortioxetine group was given vortioxetine treatment and the vortioxetine was given vortioxetine treatment.Patients were observed for 8 weeks.Before and after treatment,the clinical efficacy was evaluated by the clinical global impression(CGI).The Hamilton depression scale(HAMD)and cognitive impairment factors were used to evaluate the severity of the disease and cognitive function,and the treatment emergent symptom scale(TESS)was evaluated for adverse reactions.Results There was no statistically significant difference in the total effective rate between the two groups(P>0.05).After 2 weeks of treatment,the total scores of HAMD in both groups were significantly lower than before treatment(P<0.01),and there was no significant difference between the two groups during the same period(P>0.05).At the end of the eighth week of treatment,the cognitive impairment factor score of the vortioxetine group was significantly lower than that before the treatment(P<0.01),but there was no significant change in the venlafaxine group(P>0.05).The vortioxetine group was significantly lower than that of the venlafaxine group(P<0.05).No serious adverse reactions occurred in the two groups,and there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions Vortioxetine and venlafaxine have a fast onset,definite effect,and high safety in the treatment of depression,but the effect of vortioxetine on improving cognitive function is better than that of venlafaxine.