阿立派唑联合草酸艾司西酞普兰治疗精神分裂症合并抑郁焦虑的疗效及对血清因子的影响

Effect of aripiprazole and escitalopram on schizophrenia combined with depression and anxiety symptoms and influence of serum factors

目的分析阿立派唑联合草酸艾司西酞普兰治疗精神分裂症合并抑郁焦虑症状患者疗效及对其血清因子的影响。方法选取精神分裂症合并抑郁焦虑症状患者114例,随机分为对照组及观察组。对照组口服草酸艾司西酞普兰、齐拉西酮胶囊,观察组在上述基础上加用阿立哌唑。观察两组患者临床疗效、抑郁焦虑症状、血清炎症因子与神经功能因子等改变情况。结果治疗后观察组有效率为89.47%,高于对照组70.18%(P<0.05);治疗后1月和3月观察组汉密尔顿焦虑量表、汉密尔顿抑郁量表评分较治疗前和对照组降低(P<0.05);治疗后观察组血清肿瘤坏死因子-α、白细胞介素-2、白细胞介素-8、神经功能因子髓鞘碱性蛋白(MBP)及S100B蛋白含量较治疗前和对照组降低(P<0.05);治疗后观察组血清皮质醇、同型半胱氨酸含量较治疗前和对照组降低,脑源性神经营养因子、5-羟色胺、多巴胺含量较治疗前和对照组升高(P<0.05)。结论阿立派唑联合草酸艾司西酞普兰可有效提高精神分裂症合并抑郁焦虑症状患者疗效,降低血清炎症因子含量,改善中枢神经递质分泌。

Aim To analyze the effect of aripiprazole and escitalopram on schizophrenia combined depression and anxiety and influence of serum factors symptoms.Methods A total of 114 patients with schizophrenia combined with depression and anxiety symptoms who were treated were selected.They were randomly divided into the control group by taking escitalopram oxalate and ziprasidone capsules.Aripiprazole was added to the group on the above basis.Observe the patient s clinical efficacy,depression and anxiety symptoms,serum inflammatory factors and neurological function factors.Results The effective rate in the observation group after treatment was 89.47%,which was higher than 70.18%in the control group(P<0.05);the hamilton anxiety scale and hamilton depression scale scores in the observation group in january and march after treatment was lower than before treatment and the control group(P<0.05);After treatment,serum tumor necrosis factor-α,interleukin-2,interleukin-8,nerve function factor myelin interstitial protein and S100B protein content of the observation group were lower than before treatment and the control group(P<0.05);After treatment,the serum cortisol and homocysteine levels in the observation group were lower than those before treatment and the control group,while the levels of BDNF,serotonin and dopamine were higher than those before treatment and the control group(P<0.05).Conclusion Aripiprazole combined with escitalopram can effectively improve the curative effect of patients with schizophrenia combined with depression and anxiety,reduce the content of serum inflammatory factors,and improve the secretion of central neurotransmitters.