奥氮平对儿童精神分裂症患者临床疗效及糖脂代谢的影响

Effects of Olanzapine on Clinical Efficacy and Glucose and Lipid Metabolism in Children and Adolescents with Schizophrenia

目的:探究儿童精神分裂症(SCH)患者经奥氮平治疗后的临床疗效,以及对糖脂代谢的影响。方法:回顾性分析江西省精神病院2017年1月至2019年10月收治的54例儿童SCH患者的临床资料,根据治疗方案分组,对照组采用利培酮治疗,观察组采用奥氮平治疗,比较两组临床疗效、糖脂代谢[总胆固醇(TC)、三酰甘油(TG)、血糖(GLU)]及精神分裂症阳性与阴性症状量表(PANSS)评分。结果:观察组疗效(92.59%)与对照组(70.37%)比较,差异有统计学意义(P<0.05);治疗前,两组PANSS评分比较,差异无统计学意义(P>0.05);治疗后,两组PANSS评分低于治疗前,观察组低于对照组,差异有统计学意义(P>0.05);治疗前,两组GLU、TC、TG比较,差异无统计学意义(P>0.05);治疗后,两组GLU与治疗前比较,差异无统计学意义(P>0.05);治疗后,观察组GLU与对照组比较,差异无统计学意义(P>0.05);治疗后,两组TC、TG高于治疗前,观察组低于对照组,差异有统计学意义(P<0.05)。结论:奥氮平可提升儿童SCH患者临床疗效,改善患者临床症状,利于血脂水平稳定,同时对血糖水平影响较小。

Objective:To explore the clinical efficacy of olanzapine treatment in children schizophrenia(SCH),and the effect on glucose and lipid metabolism.Methods:A retrospective analysis of the clinical data of 54 children SCH from January 2017 to October 2019 in Jiangxi psychiatric Hospital was analyzed.According to the treatment plan,the control group was treated with risperidone,the observation group was treated with olanzapine,and the clinical efficacy,glucose and lipid metabolism[total cholesterol(TC),triacylglycerol(TG),blood glucose(GLU)]and the schizophrenia positive and negative symptom scale(PANSS)score were compared between the two groups.Results:The observation group(92.59%)compared with the control group(70.37%),the difference was statistically significant(P<0.05);before treatment,the difference between the two groups of PANSS scores was not statistically significant(P>0.05);after treatment,the PANSS score of the two groups was lower than before treatment,and the observation group was lower than the control group,the difference was statistically significant(P<0.05);before treatment,the difference between the two groups of GLU,TC,TG was not statistically significant(P>0.05);after treatment,there was no statistically significant difference in GLU between the two groups and before treatment(P>0.05);after treatment,the difference in GLU between the observation group and the control group was not statistically significant(P>0.05);after treatment,the TC and TG of the two groups were higher than before treatment,and the observation group was lower than the control group,the difference was statistically significant(P<0.05).Conclusion:Olanzapine can improve the clinical efficacy of children SCH,improve the clinical symptoms of the patients,and help stabilize blood lipid levels,while having a small effect on blood glucose levels.