双歧杆菌三联活菌联合复方谷氨酰胺对肠易激综合征患者症状改善及血清炎性因子水平的影响

Effect of Bifidobacterium Triple Viable Combined with Compound Glutamine on Symptom Improvement and Serum Inflammatory Factors in Patients with Irritable Bowel Syndrome

目的:探讨双歧杆菌三联活菌、复方谷氨酰胺联合用药在肠易激综合征(IBS)患者中的应用效果。方法:选取2019年3月至2020年6月濮阳市第五人民医院收治的93例IBS患者,随机数字表法分两组,对照组(46例)予以复方谷氨酰胺治疗,观察组(47例)在对照组基础上予以双歧杆菌三联活菌治疗,比较两组疗效、治疗前后症状改善情况[肠道症状尺度表(BSS)评分]、炎性因子[血清白介素-1β(IL-1β)、白介素-10(IL-10)及白介素-8(IL-8)]水平、不良反应发生率。结果:观察组总有效率(95.74%)高于对照组(78.26%),差异有统计学意义(P<0.05);治疗后观察组BSS评分中腹痛程度、腹胀程度、腹痛时间、排便满意度、生活干扰度评分及总分均低于对照组,差异有统计学意义(P<0.05);治疗后观察组血清IL-1β、IL-8水平低于对照组,血清IL-10水平高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:双歧杆菌三联活菌与复方谷氨酰胺联合应用于IBS患者,可明显改善临床症状,降低机体炎症反应,且不增加不良反应,安全有效。

Objective:To explore the application effect of bifidobacterium triple viable and compound glutamine in patients with irritable bowel syndrome(IBS).Methods:93 patients with IBS admitted to The Fifth People's Hospital of Puyang City from March 2019 to June 2020 were selected and randomly divided into two groups.The control group(46 cases)was treated with compound glutamine,and the observation group(47 cases)was treated with bifidobacterium triple viable on the basis of the control group.The curative effect and the improvement of symptoms before and after treatment were compared between the two groups[intestinal symptom scale(BSS)]The levels of serum IL-1β,IL-10 and IL-8,and the incidence of adverse reactions.Results:The total effective rate of the observation group(95.74%)was higher than that of the control group(78.26%),the difference was statistically significant(P<0.05);after treatment,the BSS score of the observation group in the degree of abdominal pain,degree of abdominal distension,abdominal pain time,defecation satisfaction,life disturbance score and total score were lower than those of the control group,the difference was statistically significant(P<0.05);after treatment,the serum IL-1βand IL-8 levels of the observation group were lower than those of the control group.The level of serum IL-10 was higher than that of the control group,the difference was statistically significant(P<0.05);there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The combined application of Bifidobacterium triple viable and compound glutamine in IBS patients can significantly improve the clinical symptoms,reduce the inflammatory reaction,and does not increase the incidence of adverse reactions,which is safe and effective.