噻托溴铵粉雾剂联合丙酸氟替卡松吸入气雾剂对COPD稳定期患者肺功能及炎症反应的影响

Effect of Tiotropium Bromide Powder Aerosol Combined with Fluticasone Propionate Inhalation Aerosol on Pulmonary Function and Inflammatory Reaction in Patients with Stable COPD

目的:分析噻托溴铵粉雾剂联合丙酸氟替卡松吸入气雾剂对慢性阻塞性肺疾病(COPD)稳定期患者肺功能及炎症反应的影响。方法:选取平顶山市第二人民医院接收的106例COPD稳定期患者作为研究对象,依据随机数字表法分成观察组(53例)与对照组(53例),对照组接受丙酸氟替卡松吸入气雾剂治疗,观察组接受噻托溴铵粉雾剂联合丙酸氟替卡松吸入气雾剂治疗,统计对比两组治疗前后肺功能[第1 s用力呼气容积(FEV1)、用力肺活量(FVC)、FEV1/FVC]变化、血清炎性因子[白介素-6(IL-6)、IL-8、肿瘤坏死因子-α(TNF-α)]水平以及圣乔治呼吸问卷(SGRQ)评分。结果:治疗后观察组FEV1、FVC、FEV1/FVC高于对照组(P<0.05);治疗后观察组血清TNF-α、IL-8、IL-6水平低于对照组(P<0.05);治疗后两组SGRQ评分低于治疗前,观察组低于对照组(P<0.05)。结论:噻托溴铵粉雾剂联合丙酸氟替卡松吸入气雾剂治疗COPD稳定期患者,可促进肺功能改善,减少血清炎性因子含量,提高生活质量。

Objective:To analyze the effect of tiotropium bromide powder aerosol combined with fluticasone propionate inhalation aerosol on pulmonary function and inflammatory reaction in patients with stable chronic obstructive pulmonary disease(COPD).Methods:106 patients with stable COPD in The Second People's Hospital of Pingdingshan were selected as the research objects.According to the random number table method,they were divided into the observation group(53 cases)and the control group(53 cases).The control group was treated with fluticasone propionate inhalation aerosol,and the observation group was treated with tiotropium bromide powder aerosol combined with fluticasone propionate inhalation aerosol The changes of pulmonary function(FEV1,FVC,FEV1/FVC),serum inflammatory factors(IL-6,IL-8,TNF-α)and SGRQ score were observed before and after treatment.Results:After treatment,FEV1,FVC and FEV1/FVC in the observation group were higher than those in the control group(P<0.05);after treatment,the serum levels of TNF-α,IL-8 and IL-6 in the observation group were lower than those in the control group(P<0.05);the SGRQ scores of the two groups were lower than those before treatment,and those in the observation group were lower than those in the control group(P<0.05).Conclusion:Tiotropium bromide powder aerosol combined with fluticasone propionate inhalation aerosol in the treatment of stable COPD patients can promote the improvement of lung function,reduce the content of serum inflammatory factors and improve the quality of life.