归脾丸联合复方硫酸亚铁颗粒治疗小儿缺铁性贫血60例临床疗效

Clinical Efficacy of Guipi Pill Combined with Compound Ferrous Sulfate Granules in the Treatment of 60 Children with Iron Deficiency Anemia

目的:探讨归脾丸联合复方硫酸亚铁颗粒治疗小儿缺铁性贫血(IDA)临床疗效,为临床干预提供参考。方法:采用前瞻性随机试验方法,选取2018年10月至2020年10月灵宝市第一人民医院收治的120例IDA患儿,根据随机数表法将其分为对照组60例和观察组60例。对照组口服复方硫酸亚铁颗粒治疗,观察组采用归脾丸联合复方硫酸亚铁颗粒治疗。均治疗4周,比较两组中医证候评分、铁代谢指标[血清铁(SI)、血清铁蛋白(SF)及总铁结合力(TIBC)]及不良反应。结果:治疗4周后,观察组中医证候评分低于对照组,差异有统计学意义(P<0.05);两组SI、SF水平均高于治疗前,TIBC水平均低于治疗前,差异有统计学意义(P<0.05),但组间比较,差异无统计学意义(P>0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:归脾丸联合复方硫酸亚铁颗粒治疗小儿IDA可降低中医证候评分,改善铁代谢指标,且安全性较高,值得临床应用。

Objective:To investigate the clinical efficacy of Guipi pill combined with compound ferrous sulfate granules in the treatment of iron deficiency anemia(IDA)in children,and to provide reference for clinical intervention.Methods:A prospective randomized trial method was used to select 120 IDA children in Lingbao First People's Hospital from October 2018 to October 2020.According to the random number table method,they were divided into control group(60 cases)and observation group(60 cases).The control group was treated with compound ferrous sulfate granules,and the observation group was treated with Guipi pill combined with compound ferrous sulfate granules.The TCM syndrome score,iron metabolism index[serum iron(SI),serum ferritin(SF)and total iron binding capacity(TIBC)]and adverse reactions were compared between the two groups.Results:After 4 weeks of treatment,the TCM syndrome score of the observation group was lower than that of the control group,the difference was statistically significant(P<0.05);the SI and SF levels of the two groups were higher than those before treatment,and the TIBC levels were lower than those before treatment,the difference was statistically significant(P<0.05),but there was no statistically significant difference between the two groups(P>0.05);there was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Guipi pill combined with compound ferrous sulfate granules in the treatment of IDA in children can reduce TCM syndrome score,improve iron metabolism index,and has high safety,which is worthy of clinical application.