乙酰半胱氨酸与氨溴索治疗小儿社区获得性肺炎的临床效果比较

Comparison of the clinical effects of acetylcysteine and ambroxol in the treatment of community acquired pneumonia in children

目的比较乙酰半胱氨酸与氨溴索治疗小儿社区获得性肺炎的临床效果。方法选取2016年12月至2019年12月我院收治的152例社区获得性肺炎患儿作为研究对象,将其随机分为研究组和对照组,各76例。两组均给予常规抗感染、对症支持处理,研究组给予乙酰半胱氨酸雾化吸入,对照组给予氨溴索静脉注射。比较两组的治疗效果。结果研究组的治疗总有效率为94.74%,高于对照组的78.95%,差异具有统计学意义(P<0.05)。研究组的发热、咳嗽、肺部啰音改善时间均短于对照组,差异具有统计学意义(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。治疗后,研究组的IgA、IgG水平高于对照组,差异具有统计学意义(P<0.05)。结论乙酰半胱氨酸雾化吸入治疗社区性肺炎患儿的效果优于氨溴索静脉注射,可有效改善患儿的临床症状、体征及体液免疫功能,且不良反应较少。

Objective To compare the clinical effects of acetylcysteine and ambroxol in the treatment of community acquired pneumonia in children.Methods A total of 152 children with community acquired pneumonia admitted in our hospital from December 2016 to December 2019 were selected as the research objects and randomly divided into study group and control group,with 76 cases in each group.Both groups were given routine anti-infection and symptomatic support treatment.The study group was given acetylcysteine aerosol inhalation,and the control group was given ambroxol intravenous.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the study group was 94.74%,which was higher than 78.95%in the control group,and the difference was statistically significant(P<0.05).The improvement time of fever,cough and pulmonary rales in the study group were shorter than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).After treatment,the levels of IgA and IgG in the study group were higher than those in the control group,and the difference was statistically significant(P<0.05).Conclusion Acetylcysteine atomization inhalation in the treatment of children with community acquired pneumonia has better effect compared with ambroxol intravenous,which can effectively improve the clinical symptoms,signs and humoral immune function of children,with less adverse reactions.