摘要
Recently,Prof.Ming 0.Li and colleagues published two back-toback studies in Nature,demonstrating that blocking transforming growth factor β(TGF-β)signaling in CD4^(+) T cells leads to tissue healing and remodeling of the blood vasculature,causing cancer cell hypoxia and death in distant avascular regions.1 Furthermore,they also provide direct evidence validating that the above strategy does restrain cancer progression in a mouse model of breast cancer resistant to immune-checkpoint or anti-VEGF therapies.
基金
This work was supported by the Chinese National Natural Science Funds(U20A201376,81902947,82041009,31925013,31671457,31701234,91753139,and 31871405)
a special program from the Ministry of Science and Technology of China(2016YFA0502500)
Jiangsu Provincial Distinguished Young Scholars award(BK20180043)
the Key Project of University Natural Science Foundation of Jiangsu Province(19KJA550003)
A project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions and the Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX17_2036).
