摘要
Dear Editor,Almost one-half of COVID-19 patients have symptoms of liver injury.However,the molecular characteristics in the COVID-19 liver remain unknown.Therefore,the need for long-term medication for recovery make it imperative to study the infectivity and pathogenicity of SARS-CoV-2 in the liver.Here,we have identifed signifcant proteomic changes for the first time in the liver of COVID-19 patients.We detected differential expression levels of several proteins that mediate characteristic cellular host responses elicited by SARS-CoV-2 infection in the liver.
基金
This work was supported by the National Science and Technology Major Projects(2018ZX09711003)
National Key Research and Development Project(2020YFC0841700)
Ministry of Science and Technology of P.R.China Plan(2020YFC0844700).
