摘要
As one of the most successful therapeutic target families,G protein-coupled receptors(GPCRs)have experienced a transformation from random ligand screening to knowledge-driven drug design.We are eye-witnessing tremendous progresses made recently in the understanding of their structure-function relationships that facilitated drug development at an unprecedented pace.This article intends to provide a comprehensive overview of this important field to a broader readership that shares some common interests in drug discovery.
基金
The authors acknowledge funding support from the National Natural Science Foundation of China 81872915(to M.-W.W.),81773792(to D.Y.),81973373(to D.Y.),21704064(to Q.Z.),31971362(to W.S.),31971178(to S.Z.),and 31770796(to Y.J.)
National Science&Technology Major Project of China-Key New Drug Creation and Manufacturing Program 2018ZX09735-001(to M.-W.W.),2018ZX09711002-002-005(to D.Y.),and 2018ZX09711002-002-002(to Y.J.)
the National Key Basic Research Program of China 2018YFA0507000(to M.-W.W.,S.Z.,W.S.,and H.T.)
Novo Nordisk-CAS Research Fund grant NNCAS-2017-1-CC(to D.Y.)
The Belt and Road Master Fellowship program(to V.L.)
UCAS Scholarship for International Students(to S.D.)
and The CAS-TWAS President's Fellowship for International Doctoral Students(to E.Y.).
