高龄女性移植2枚或3枚卵裂期胚胎的临床效果比较

Comparison of clinical outcome between 2 and 3 embryos transfer for elderly women

目的探讨移植2枚或3枚胚胎与临床结局的关系,为高龄女性胚胎移植数的选择提供依据。方法对80个卵裂期胚胎新鲜移植周期进行回顾性分析,根据移植胚胎数将这些周期分组,并对各组的临床妊娠率、种植率、多胎妊娠率及活产率进行比较。结果对于年龄≥38岁的女性,当可利用胚胎数≥3枚时,移植2枚胚胎与移植3枚胚胎能够获得相似的临床妊娠率及活产率。这一趋势与所移植的8-细胞胚胎数无关。结论高龄女性新鲜卵裂期胚胎移植数目不宜超过2枚。

Objective To explore the relationship between clinical outcomes and embryo transfer number,and to provide some proposals for transfer selection of elderly patients.Methods Data from 80 fresh transfer cycles with cleavagestage embryos were analyzed.Cycles were divided into several groups according to transfer number.Clinical pregnancy rate,implantation rate,multiple pregnancy rate and live birth rate were compared.Results To women no younger than 38 years old,when available embryo number was larger than two,similar clinical outcomes could be achieved by transferring two and three embryos.This trend was independent of the number of transferred 8-cell embryos.Conclusion The number of fresh cleavage-stage embryos transfer should not exceed two in elderly women.