鞘脂代谢与心血管疾病关系的研究进展

Review on the relationship between sphingolipid metabolism and cardiovascular diseases

鞘脂作为一种生物活性脂质,可参与生长、凋亡等多种重要生理过程的信号转导,且在包括心血管疾病在内的多种疾病状态中表现出了异常水平,提示鞘脂代谢参与心血管疾病的发生发展。本文中我们对鞘脂代谢过程及其代谢产物与冠心病、高血压、心律失常、心力衰竭这4种心血管系统常见病的关系、作用机制进行综述,并对鞘脂通路作为心血管疾病诊治潜在靶点提出了展望。

As bioactive lipids,sphingolipids participate in the signal transduction of many important physiological processes such as growth and apoptosis.Besides,abnormal levels of sphingolipids were detected in a variety of clinical conditions including hypertension and coronary heart disease,suggesting that sphingolipid metabolism is involved in the occurrence and development of cardiovascular diseases.This paper reviewed the relationship between sphingolipid metabolism with four common cardiovascular diseases,coronary heart disease,hypertension,arrhythmia and heart failure,and the mechanisms involved.What’s more,the prospect of sphingolipid pathway as a potential target for the diagnosis and treatment of cardiovascular diseases is put forward.