左心耳形态结构和功能与心房颤动相关性卒中的研究和展望

Research and prospect of left atrial appendage morphology and function in atrial fibrillation stroke

心房颤动(房颤)是临床最常见的持续性心律失常,房颤患者缺血性卒中的风险较非房颤患者明显增高,而其血栓主要来源于左心耳(LAA)。长期以来,非瓣膜性房颤患者的抗凝原则主要依据CHA2DS2-VASc评分,但是对于中低危患者存在局限性。随着医学影像学的发展,学者们发现左心耳形态结构特征和功能参数与血栓形成有关,可潜在地用于预测房颤卒中的发生。故本文拟对此进行综述,以期为下一步研究提供思路。

Atrial fibrillation is the most common clinical persistent arrhythmia.The risk of ischemic stroke in patients with atrial fibrillation is significantly higher than that in patients without atrial fibrillation and the thrombus mainly originates from the left atrial appendage(LAA).For a long time,the principle of anticoagulation for patients with nonvalvular atrial fibrillation is mainly based on the CHA2 DS2-VASC score,but there are limitations for low-and medium-risk patients.With the development of medical imaging,scholars have discovered that the morphological and structural characteristics and functional parameters of the left atrial appendage are related to thrombosis,which can potentially be used to predict the occurrence of atrial fibrillation and stroke.Therefore,this article intends to review these in order to provide ideas for further research.