Netrin-1 marshals mitochondrial movement,morphology,and metabolism in myelin

Oligodendrocytes are the myelinating cells of the central nervous system(CNS)that ensheath nearby axons to support action potential propagation and axon metabolism.Myelination involves the rapid production of lipid-rich membrane,compaction of the multilamellar myelin sheath,and the resultant restriction of cytoplasm to non-compact compartments.During myelination,septate-like junctions form between the axon and lateral cytoplasmic endings of the myelin sheath at a specialized domain called the paranode(Figure 1A).