摘要
VSIG4(the protein V-set and immune globulin domain-containing 4)是一种与巨噬细胞蛋白质相关的新的B7相关免疫球蛋白的Ⅰ型跨膜蛋白,具有抑制T细胞活化的能力,也被称为CRIg(免疫球蛋白超家族)和Z39Ig,在病原体识别和清除中起关键作用。恶性肿瘤中,VSIG4的表达及VSIG4阳性T细胞的增加可能预示更高的侵袭性和复发风险。全文就VSIG4与各肿瘤间的关系作一简要概述,为VSIG4与恶性肿瘤诊治提供参考。
The protein V-set and immunoglobulin domain containing protein 4(VSIG4),also known as CRIg and Z39Ig,is a novel typeⅠtransmembrane protein of B7-related immunoglobulin superfamily and a negative regulator of T cell activation,which plays a key role in pathogen identification and clearance.In malignant tumors,the expression of VSIG4 and the increase of VSIG4 positive T cells may indicate higher aggressiveness and greater risk of recurrence.This article gives a brief overview of the relationship between VSIG4 and various cancer,and provides references for application of VSIG4 in the diagnosis and treatment of malignant tumors.
作者
许世莹
黄煜庆
郑国湾
王佳峰
蒋烈浩
葛明华
XU Shi-ying;HUANG Yu-qing;ZHENG Guo-wan;WANG Jia-feng;JIANG Lie-hao;GE Ming-hua(Second Clinical Medical College,Zhejiang Chinese Medical University,Hangzhou 310053,China;The First People’s Hospital of Xiaoshan District,Hangzhou 311200,China;Zhejiang Provincial People’s Hospital,Hangzhou 310014,China)
出处
《肿瘤学杂志》
CAS
2021年第2期148-152,共5页
Journal of Chinese Oncology
