梅花针叩刺联合氨酚羟考酮治疗肺癌术后慢性疼痛的效果观察

Clinical observation on plum-blossom needle combined with oxycodone and acetaminophen in the treatment of chronic pain after lung cancer operation

目的探讨梅花针叩刺联合氨酚羟考酮治疗肺癌术后慢性疼痛的效果。方法选取术后慢性疼痛的肺癌患者72例,采用区域化随机分组法将其分为试验组与对照组,每组36例。试验组采用梅花针叩刺联合氨酚羟考酮口服治疗,对照组采用氨酚羟考酮口服治疗。评估两组患者治疗前后的疼痛数字等级评定量表(NRS)评分、卡氏功能状态(KPS)评分、简明疼痛评估量表(BPI)评分、中医症状量化评分及血清白细胞介素-6(IL-6)水平。结果治疗后,试验组患者的NRS评分、IL-6水平均低于对照组,KPS评分高于对照组(P﹤0.05)。试验组的疼痛缓解率、KPS改善有效率、中医症候改善有效率均高于对照组(P﹤0.05)。试验组BPI中的日常生活、情绪、行走能力、与他人之间的关系、睡眠5项指标的评分均低于对照组(P﹤0.05);中医症状量化评分中的胸痛、心烦失眠、便秘、舌象、脉象评分均低于对照组(P﹤0.05)。结论梅花针叩刺联合氨酚羟考酮可以有效缓解肺癌患者的术后慢性疼痛,减少疼痛对患者生活的影响,改善中医证候,整体调节患者术后气滞血瘀的病理状态,从而减轻患者痛苦,提高生活质量,具有一定临床应用价值。

Objective To explore the effect of plum-blossom needle tapping combined with oxycodone and acetaminophen on postoperative chronic pain in patients with lung cancer.Method A total of 72 patients with postoperative chronic pain of lung cancer were selected.According to regional random grouping method the patients were randomly divided into experimental group(n=36)and control group(n=36).The experimental group was treated with plum-blossom needle tapping combined with oxycodone and acetaminophen,the control group was treated with oxycodone and acetaminophen.After 28 days of treatment,the numerical rating scale(NRS)score,Karnofsky functional status(KPS)score,brief pain inventory(BPI)score,traditional Chinese medicine quantitative score and serum interleukin-6(IL-6)levels in the two groups were evaluated before and after treatment.Result After treatment,the NRS score and the level of IL-6 in the experimental group were lower than those in the control group(P<0.05).The KPS score was higher than that in the control group(P<0.05).After treatment,the pain relief rate,the effective rate of KPS improvement and the effective rate of traditional Chinese medicine syndrome improvement of the experimental group was higher than that of the control group(P<0.05).The BPI scores of daily life,mood,walking ability,relationship with others and sleep affected by pain in the experimental group were lower than those in the control group(P<0.05).In the quantitative score of traditional Chinese medicine,the scores of chest pain,restlessness,constipation,tongue and pulse in the experimental group were lower than those in the control group(P<0.05).Conclusion Plum-blossom needle combined with oxycodone and acetaminophen can effectively relieve postoperative chronic pain in patients with lung cancer,reduce the impact of pain on patients’life,improve traditional Chinese medicine syndromes,and overall regulate the pathological state of postoperative qi stagnation and blood stasis,so as to reduce patients’pain and improve the quality of life of tumor patients,which has a certain clinical application value.