术后同步放化疗对恶性脑胶质瘤患者临床疗效及预后的影响

Effect of postoperative concurrent radiochemotherapy on the clinical efficacy and prognosis of patients with malignant glioma

目的探讨术后同步放化疗对恶性脑胶质瘤患者临床疗效及预后的影响。方法依据治疗方案将200例恶性脑胶质瘤患者分为对照组和观察组,每组100例,对照组患者术后接受单纯放疗,观察组患者术后予以同步放化疗。比较两组患者的近远期疗效,不良反应发生情况,生活质量和随访1、2年的生存率。结果治疗后,观察组患者的治疗总有效率和不良反应总发生率均明显高于对照组患者,差异均有统计学意义(P﹤0.01)。治疗前,两组患者卡式功能状态(KPS)评分比较,差异均无统计学意义(P﹥0.05)。治疗后即刻、治疗后3个月,两组患者的KPS评分均高于本组治疗前,且对照组患者的KPS评分均高于观察组患者,差异均有统计学意义(P﹤0.05)。随访1、2年,观察组患者的生存率分别为78.00%、62.00%,均高于对照组患者的54.00%、31.00%,差异均有统计学意义(P﹤0.05)。结论术后同步放化疗可明显提高恶性脑胶质瘤患者的近期疗效和生存率,但不良反应较多,生活质量较低。

Objective To explore the effect of postoperative concurrent radiochemotherapy and chemotherapy on the clinical efficacy and prognosis of patients with malignant glioma.Method According to the treatment plan,200 patients with malignant glioma were divided into a control group and an observation group,each with 100 cases.The control group received postoperative radiotherapy alone,and the observation group received concurrent radiochemotherapy.The short-and long-term efficacy,incidence of adverse reactions,quality of life and the survival rate of 1-and 2-years of follow-up were compared between the two groups.Result After treatment,the total effective rate of treatment and the total incidence of adverse reactions in the observation group were significantly higher than those in the control group,and the differences were statistically significant(P<0.01).Before treatment,there was no statistically significant difference in Karnofsky performance status(KPS)scores between the two groups of patients(P>0.05).Immediately after treatment and 3 months after treatment,the KPS scores of the two groups of patients were higher than those of the group before treatment,and the KPS scores of the control group were higher than those of the observation group,the differences were statistically significant(P<0.05).After 1 and 2 years of follow-up,the survival rates of patients in the observation group were 78.00%and 62.00%,respectively,which were higher than those of 54.00%and 31.00%in the control group,the differences were statistically significant(P<0.05).Conclusion Postoperative concurrent radiochemotherapy can significantly improve the short-term efficacy and survival rate of patients with malignant gliomas,but with more complications and lower quality of life.