舒肝解郁胶囊联合氟西汀治疗脑卒中后抑郁临床研究

Clinical Study on Shugan Jieyu Capsules Combined with Fluoxetine for Post-Stroke Depression

目的:观察舒肝解郁胶囊联合氟西汀治疗脑卒中后抑郁的临床疗效。方法:选取74例脑卒中后抑郁患者,按随机数字表法分为对照组和观察组,每组37例。2组均给予常规脑卒中治疗,控制相关危险因素,对照组在此基础上加用盐酸氟西汀分散片治疗,观察组在对照组基础上加用舒肝解郁胶囊治疗。观察2组抑郁程度、认知功能、神经功能及运动功能的改善情况,比较2组临床疗效及不良反应发生率。结果:治疗后,2组简明精神状态量表(MMSE)、简式Fugl-Meyer运动功能评估量表(FMA)评分均较治疗前升高(P<0.05),抑郁自评量表(SDS)、美国国立卫生研究院卒中量表(NIHSS)评分均较治疗前降低(P<0.05);观察组MMSE、FMA评分均高于对照组(P<0.05),SDS、NIHSS评分均低于对照组(P<0.05)。观察组临床疗效优于对照组,差异有统计学意义(Z=1.825,P<0.05)。2组恶心呕吐、口干、便秘及性功能障碍发生率比较,差异均无统计学意义(P>0.05)。结论:舒肝解郁胶囊联合氟西汀治疗脑卒中后抑郁,可以明显改善患者的抑郁状况,提升其认知功能、神经功能与运动功能。

Objective:To observe the clinical effect of Shugan Jieyu capsules combined with fluoxetine for post-stroke depression. Methods:A total of 74 cases of patients with post-stroke depression were divided into the control group and the observation group according to the random number table method,37 cases in each group. Both groups were given routine stroke treatment to control related risks factors;the control group was additionally treated with fluoxetine hydrochloride dispersible tablets,and the observation group was additionally treated with Shugan Jieyu capsules based on the treatment of the control group. The improvement of depressive degree, cognitive function, neurological function and motor function in the two groups were observed. The clinical effect and the incidence of adverse reactions in the two groups were compared.Results:After treatment,the scores of Mini-Mental State Examination(MMSE) and short-form Fugl-Meyer Assessment(FMA) in the two groups were increased when compared with those before treatment(P<0.05),and the scores of Self-rating Depressing Scale(SDS) and National Institute of Health Stroke Scale(NIHSS) were decreased(P<0.05);the scores of MMSE and FMA in the observation group were higher than those in the control group(P<0.05),and the scores of SDS and NIHSS were lower(P<0.05). The clinical effect in the observation group was better than that in the control group, the difference being significant(Z=1.825,P<0.05). There was no significant difference being found in the comparison of the incidences of nausea and vomiting, dry mouth, constipation and sexual dysfunction between the two groups(P>0.05). Conclusion:Shugan Jieyu capsules combined with fluoxetine for post-stroke depression can significantly improve the depressive degree,cognitive function,neurological function and motor function of patients.