小儿肺咳颗粒与盐酸氨溴索糖浆治疗小儿慢性咳嗽临床对比研究

Clinical Comparative Study Between Xiao’er Feike Granules and Ambroxol Hydrochloride Syrup for Chronic Cough in Children

目的:对比分析小儿肺咳颗粒与盐酸氨溴索糖浆治疗小儿慢性咳嗽的临床应用价值。方法:将慢性咳嗽患儿200例按数字奇偶法分为研究组与对照组各100例,2组入院后均临床接受常规治疗,在此基础上,对照组给予盐酸氨溴索糖浆治疗,研究组给予小儿肺咳颗粒治疗,连续治疗2周后评估2组患儿临床症状体征变化并评定临床疗效,同时检测其免疫功能指标。结果:总有效率研究组93.00%高于对照组的67.00%,差异有统计学意义(P<0.05)。治疗前,2组中医证候积分比较,差异无统计学意义(P>0.05)。治疗后,2组中医证候积分均下降,研究组低于对照组,差异有统计学意义(P<0.05)。咳嗽缓解时间、咳嗽消失时间研究组早于对照组,差异有统计学意义(P<0.05)。治疗前,2组CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)比较,差异无统计学意义(P>0.05)。治疗后,2组CD8^(+)与治疗前比较上升,研究组CD8^(+)上升幅度大于对照组;2组CD4^(+)、CD4^(+)/CD8^(+)与治疗前比较下降,研究组CD4^(+)、CD4^(+)/CD8^(+)下降幅度大于对照组,差异均有统计学意义(P<0.05)。结论:小儿肺咳颗粒治疗小儿慢性咳嗽与盐酸氨溴索糖浆比较,更有利于提升临床疗效,缓解患儿临床症状,并能提高患儿免疫抵抗力。

Objective: To compare and analyze the clinical application value of Xiao’er Feike granules and ambroxol hydrochloride syrup in the treatment of chronic cough in children. Methods:A total of 200 children with chronic cough were divided into the study group and the control group,100 cases each,by digital parity. Based on the routine treatment,the control group was additionally treated with ambroxol hydrochloride syrup,and the study group was additionally treated with Xiao’er Feike granules. After two weeks of treatment, the clinical symptoms and signs in the two groups and the clinical effect were evaluated,and the immune function. Results:The total effective rate in the study group of 93.00% was higher than what was 67.00% in the control group,which was statistically significant(P<0.05). Before treatment,the difference in the comparison of Chinese medicine syndrome scores between the two groups was no significant(P>0.05). After treatment,the Chinese medicine syndrome scores in the two groups were decreased and the scores was statistically significant between the study group and the control group(P<0.05). The cough relief time and cough disappearance time in the study group were earlier, what were statistically significant, than those in the control group(P<0.05). There was no significant difference before treatment in the comparison of the levels of CD4^(+),CD8^(+),CD4^(+)/CD8^(+)between all groups(P>0.05). After treatment,the levels of CD8^(+)in the two groups were increased and the level of the study group was greater than that of the control group;the levels of CD4^(+)and CD4^(+)/CD8^(+)were decreased and the level of the study group were greater,which was statistically significant,than those in the control group(P<0.05). Conclusion:Compared with ambroxol hydrochloride syrup,Xiao’er Feike granules is more beneficial to improving the clinical effect,relieving the clinical symptoms and improving the immune resistance of children.