^(131)I联合帕罗西汀对甲状腺功能亢进伴情绪障碍患者的效果

Effect of iodine 131 combined with paroxetine in hyperthyroidism patients with mood disorders

目的观察^(131)I联合帕罗西汀治疗甲亢伴情绪障碍患者的临床效果及其对甲状腺功能的影响。方法选取我科2018年6月~2019年10月期间收治的109例甲状腺功能亢进伴情绪障碍患者作为研究对象,对照组54例给予^(131)I治疗,观察组55例在对照组基础上加用帕罗西汀治疗,治疗两个月后对比两组患者的临床疗效、促甲状腺素(TSH)、游离甲状腺素(FT4)、游离三碘甲状腺原氨酸(FT3)水平和焦虑情况评分、抑郁情况评分、症状自评量表(SCL-90),以及两组用药后不良反应的发生情况。结果治疗后观察组总有效率为92.73%明显高于对照组的74.07%(P<0.05);治疗后两组患者体内TSH、FT4、FT3水平明显优于治疗前(P<0.05),治疗后观察组体内TSH、FT4、FT3水平明显优于对照组(P<0.05);治疗后两组患者SAS、SDS评分明显优于治疗前(P<0.05),治疗后观察组SAS、SDS评分明显优于对照组(P<0.05);两组患者不良反应发生率对比无统计学意义(P>0.05)。结论^(131)I联合帕罗西汀能明显提高甲状腺功能亢进症伴情绪障碍患者的临床疗效,改善患者TSH、FT4、FT3水平,消除焦虑、抑郁情绪。

Objective To observe the clinical effect of iodine 131 combined with paroxetine in the treatment of hyperthyroidism patients with mood disorders.Methods From June 2018 to October 2019,109 hyperthyroidism patients with mood disorders in our department were selected as the research objects.54 patients in the control group were treated with iodine 131,and 55 patients in the observation group were treated with paroxetine on the basis of the control group.After two months of treatment,the clinical efficacy,thyroid stimulating hormone(TSH),free thyroxine(FT4),free triiodothyronine(FT3)levels,anxiety score,depression score,and symptoms were compared between the two groups of patients,and the occurrence of adverse reactions between the two groups were compared.Results After treatment,the total effective rate of the observation group was 92.73%,which was significantly higher than that(74.07%)of the control group(P<0.05).After treatment,the levels of TSH,FT4 and FT3 in the two groups were significantly better than those before treatment(P<0.05).The levels of TSH,FT4,and FT3 in the observation group were significantly better than those in the control group(P<0.05).The SAS and SDS scores of the two groups after treatment were significantly better than those before the treatment(P<0.05),and the SAS and SDS scores in the observation group were significantly better after treatment It was better than the control group(P<0.05).The incidence of adverse reactions between the two groups was not statistically difference(P>0.05).Conclusion Paroxetine combined with iodine 131can significantly improve the clinical efficacy and the levels of TSH,FT4,FT3 in hyperthyroidism patients with mood disorders,and eliminate their anxiety and depression.