氢溴酸西酞普兰对缺血性脑卒中后抑郁患者的情绪、认知功能和神经功能的影响

Effects of citalopram hydrobromide on depression,cognitive function and nerve function in patients with depression after ischemic stroke

目的探讨氢溴酸西酞普兰联合奥扎格雷钠对缺血性脑卒中后抑郁患者的情绪、认知功能和神经功能的影响。方法选取我科2017年7月~2019年7月期间收治的119例缺血性脑卒中后抑郁患者作为研究对象,采用随机数字表法分为2组,均给予奥扎格雷钠作为基础治疗,对照组59例增加氟西汀治疗,观察组60例增加氢溴酸西酞普兰治疗,16周后,对比两组患者临床疗效、抑郁状态、认知功能、神经功能和药物安全性。结果观察组治疗后有效率91.67%(55/60)高于对照组76.27%(45/59)(P<0.05);两组治疗方案均可降低患者治疗后汉密尔顿抑郁量表(HAMD-17)评分和提高简易精神状态量表(MMSE)评分,但观察组降低HAMD-17评分和提高MMSE评分幅度高于对照组(P<0.05);两组治疗方案均可降低患者治疗后的美国国立卫生研究院卒中量表(NIHSS)评分和提高巴氏量表(Barthel指数),但观察组降低NIHSS评分和提高Barthel指数高于对照组(P<0.05);观察组在治疗期间西酞普兰平均用药量(23.68±3.49)mg略低于对照组氟西汀平均用药量(27.73±3.56)mg(t=6.2667,P<0.05)。结论氢溴酸西酞普兰联合奥扎格雷钠治疗缺血性脑卒中后抑郁患者效果确切,能够更好改善患者的抑郁状态,提高认知功能,促进神经功能的恢复,提高日常生活活动能力。

Objective To analyze the effect of citalopram hydrobromide combined with sodium ozagrel on depression,cognitive function and neurological function in patients with depression after ischemic stroke.Methods From July 2017 to July 2019,119 patients with depression after ischemic stroke in our department were selected and divided into two groups by random number table method,and both were given ozagrel sodium as the basic treatment.59 cases in the group were treated with fluoxetine,and 60 cases in the observation group were treated with citalopram hydrobromide.After 16 weeks,the clinical efficacy,depression status,cognitive function,neurological function and drug safety of the two groups were compared.Results The effective rate of the observation group was 91.67%(55/60),which was higher than that of the control group 76.27%(45/59)(P<0.05).Both treatment regimens could reduce the Hamilton Depression Scale(HAMD-17)Scoring and improving the Mini-Mental State Scale(MMSE)score,but the observation group decreased the HAMD-17 score and increased the MMSE score more than the control group(P<0.05).Both treatment options can reduce the patient’s post-treatment US National The NIHSS score and the increase Barthel scale(Barthel index),but the observation group decreased the NIHSS score and increased the Barthel index more than the control group(P<0.05).The average dosage of fluoxetine in the Observation Group(23.68±3.49)MG was slightly lower than that in the control group(27.73±3.56)MG(t=6.2667,P<0.05).Conclusion Citalopram hydrobromide combined with ozagrel sodium has a definite effect in the treatment of post-ischemic stroke patients with depression.It can significantly improve the patient’s depression,improve cognitive function,promote the recovery of nerve function,and improve the ability of daily life activities.