帕罗西汀联合心理治疗对产后抑郁患者负面情绪及睡眠质量的影响

Effect of paroxetine combined with psychotherapy on negative mood and sleep quality in patients with postpartum depression

目的探讨帕罗西汀联合心理治疗对产后抑郁患者负面情绪及睡眠质量的影响。方法选取2017年1月~2019年6月我院收治的111例产后抑郁症患者作为主要研究对象。按随机数字表法将研究对象随机分为观察组和对照组,两组患者均接受心理治疗。在此基础上,对照组(55例)给予马普替林治疗,观察组(56例)给予帕罗西汀治疗,观察对比两组患者治疗前后汉密尔顿抑郁量表(HAMD)评分、匹茨堡睡眠质量指数量表评分(PSQI)和神经递质水平、神经营养因子水平,及治疗后临床疗效和简明健康状况调查表(SF-36)评分。结果治疗后,观察组患者HAMD、PSQI评分低于对照组(P<0.05),SF-36评分、5-HT、BDNF水平及总有效率高于对照组(P<0.05)。结论帕罗西汀联合心理治疗能够有效缓解产后抑郁患者负面情绪,改善睡眠质量,提升其生活质量。

Objective To analyze effect of paroxetine combined with psychotherapy on negative mood and sleep quality in patients with postpartum depression.Methods A total of 111 patients with postpartum depression in our hospital from January 2017 to June 2019 were collected and randomly divided into two groups:Both groups received psychotherapy.On this basis,the control group(55 cases)was treated with maptidine,and the observation group(56 cases)with paxil.Hamilton depression scale(HAMD)score,Pittsburgh sleep quality index scale(PSQI)score,serum neurotransmitter level,neurotrophic factor level before and after treatment,and clinical efficacy and 36-item shot-form health status survey(SF-36)score after treatment were observed and compared between the two groups.Results After treatment,the HAMD and PSQI scores in the observation group were lower than those in the control group,and the SF-36 score,5-HT,and BDNF levels and the total effective rate in the observation group were higher than those in the control group(P<0.05).Conclusion Paroxetine combined with psychotherapy can effectively alleviate negative emotions,improve sleep quality and quality of life in patients with postpartum depression.The mechanism may be related to regulating 5-HT and BDNF levels.