盐酸纳布啡注射液用于剖宫产术后镇痛对产后抑郁的影响

Effect of nabulphine hydrochloride injection on postpartum depression after cesarean section

目的探讨采用盐酸纳布啡注射液进行剖宫产术后镇痛对产后抑郁的影响。方法选取2018年1月~2019年1月在我院接受剖宫产术产妇200例为主要研究对象,按随机数字表法将研究对象随机分为观察组和对照组,每组各100例。对照组采用舒芬太尼镇痛,观察组采用盐酸纳布啡注射液镇痛。观察比较两组产妇术后各时点疼痛视觉模拟评分(VAS)、Ramsay镇静评分(RSS)抑郁自评量表(SDS)评分及不良反应。结果观察组产妇术后6h、12h、24h、48h、72h时VAS、RSS评分较对照组低(P<0.05或P<0.01);观察组产妇术后3d、7d、15d、30d、90d时SDS评分均较对照组低(P<0.01);观察组产妇术后不良反应和产后抑郁发生率均较对照组低(P<0.01)。结论剖宫产术后镇痛中采用盐酸纳布啡注射液可减轻产妇术后疼痛降低产后抑郁发生率,不良反应少,安全性高,值得推广。

Objective To investigate the effect of nabulphine hydrochloride injection on postpartum depression after cesarean section.Methods A total of 200 parturient women receiving cesarean section in our hospital were collectedand randomly divided into two groups:observation group(100cases)was treated with nabufine hydrochloride injection,control group(100cases)was treated with sufentanil.Visual analogue pain score(VAS),Ramsay sedation score(RSS),self-rating depression scale(SDS)score,and adverse reactions between the two groups were compared.Results The VAS and RSS scores in the observation group at 6h,12h,24h,48h and 72h after surgery were lower than those in the control group(P<0.05 or P<0.01).The SDS score in the observation group was lower than that in the control group at 3d,7d,15d,30d and 90d(P<0.01).The incidence of postoperative adverse reactions and postpartum depression in the observation group was lower than that in the control group(P<0.01).Conclusion The use of nabulphine hydrochloride injection in postoperative analgesia after cesarean section can reduce postoperative pain,reduce the incidence of postpartum depression,less adverse reactions and high safety,which is worthy of promoting.