双酚A对脂代谢影响的研究进展

Research progress on effect of bisphenol A on lipid metabolism

双酚A(BPA)是一种典型的环境内分泌干扰物,常出现在日常生活用品及某些医疗器械中。近年来,BPA对脂代谢产生的不良影响引起了人们的广泛关注,相关流行病学研究的结果并不完全一致。实验研究表明,BPA可诱发肥胖、脂代谢异常、炎症氧化应激、相关信号通路和脂代谢基因的改变。研究提示,表观遗传改变是BPA发挥致肥效应的主要原因,自噬和微核糖核酸也在其中发挥了重要的作用。本文概括了BPA对脂代谢所造成的不良影响,阐述了可能涉及到的相关机制。对于BPA暴露所引发的脂质蓄积的毒性机制仍待深入探究,今后应开展更为广泛的人群纵向研究,以获取更为可靠的流行病学依据。

Bisphenol A(BPA), a typical environmental endocrine disruptor, is often found in daily necessities and some medical devices. In recent years, the adverse effects of BPA on lipid metabolism have aroused widespread concerns, and the results of related epidemiological studies are not completely consistent. Experimental studies have shown that BPA can induce obesity, abnormal lipid metabolism, inflammatory oxidative stress, and changes in related signal pathways and lipid metabolism genes. It is suggested that epigenetic change is the main cause of the fattening effect of BPA, and autophagy and microRNA may also play an important role. This paper summarized the reported adverse effects of BPA on lipid metabolism and expounded the related mechanisms that may be involved. The toxic mechanism of lipid accumulation caused by BPA exposure remains to be further explored in more extensive longitudinal population studies to obtain more reliable epidemiological evidence.