摘要
砷化合物三氧化二砷、硫化砷在人类血液系统恶性肿瘤和实体瘤临床治疗方面表现出了显著的疗效。砷剂能够诱导肿瘤细胞分化、凋亡、自噬,消除白血病起始细胞,直接作用于靶蛋白。文章将对砷剂在各种肿瘤中作用机制的研究进展进行综述,以利于深入理解砷剂复杂的抗肿瘤作用机制,拓展其肿瘤治疗谱。
The arsenic compounds including arsenic trioxide and arsenic sulfide have played a crucial role in the clinical treatment of hematologic malignancies and solid tumors.Arsenic agents can induce tumor cells differentiation,apoptosis and autophagy,eliminate leukemia-initiating cells,and directly bind to the target proteins.This paper reviews the mechanism progress of arsenic agents in various tumors to further understand the intricate anti-tumor mechanisms of arsenic agents and to expand its therapeutic spectrum.
作者
文柏清
康亚妮
毛建华
Wen Baiqing;Kang Yani;Mao Jianhua(School of Biomedical Engineering,Shanghai Jiao Tong University,Shanghai 200240,China;State Key Laboratory of Medical Genomics,Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Institute of Hematology,Shanghai 200025,China)
出处
《肿瘤研究与临床》
CAS
2021年第2期146-149,共4页
Cancer Research and Clinic
基金
国家自然科学基金(81101721)
上海市自然科学基金(16ZR1421000)
上海市卫生健康委员会面上项目(201940342)
上海市浦江人才计划(16PJ1406100)。
关键词
砷剂
血液肿瘤
肿瘤
分子靶向治疗
Arsenicals
Hematologic neoplasms
Neoplasms
Molecular targeted therapy
