新型冠状病毒肺炎的病理学特征

Pathological characteristics of COVID-19

新型冠状病毒病19(COVID-19)感染引起全身严重疾病并伴有肺功能不全。本文对近期发表的61例患者的病理学观察结果进行总结,发现肺脏组织学特征为:急性期弥漫性肺泡损伤、肺水肿、肺透明膜形成、弥漫性肺泡损伤、蛋白和纤维蛋白渗出,可见多核肺细胞;大多数病例有不同程度出血和血栓形成;浸润以淋巴细胞和单核细胞为主;免疫组化和电镜结果均显示Ⅱ型肺泡上皮细胞受损增生,其细胞胞浆和肺泡含有冠状病毒阳性成分。心脏、肝脏、肾和脾未见明显特征性病理改变。

Coronavirus disease 19(COVID-19)infection causes severe systemic diseases with pulmonary insufficiency.The recently published pathological observation of 61 patients were summarized.The histological features of the lung include diffuse alveolar damage,pulmonary edema,hyaline membrane formation,diffuse alveolar injury,protein and fibrin exudation,and multinucleated lung cells.Most cases had bleeding and thrombosis in varying degrees,the infiltrations were mainly lymphocytes and monocytes.The results of immunohistochemistry and electron microscopy showed that type II alveolar epithelial cells were damaged and proliferated,and the cytoplasm and alveoli contained coronavirus positive components.No obvious pathological changes were found in heart,liver,kidney and spleen.