青年高血压患者视觉随意注意的事件相关电位

Dysfunction of visual attention in young patients with hypertension:an event-related potentials study

目的探讨青年高血压对视觉随意注意的影响。方法采用事件相关电位成分P300,对24名青年原发性高血压患者及23名正常对照者的视觉随意注意进行评价。结果正常组P300的波幅平均值为(6.10±0.59)μV,高血压组P300的波幅平均值为(4.09±0.59)μV,高血压组波幅平均值显著降低(F=4.73,P<0.05),其中顶区位置下降最明显(P<0.05);高血压组P300潜伏期(401.31±6.27)ms较正常组(391.34±6.13)ms延长,但差异无统计学意义(P>0.05);视觉P300波幅与MMSE得分为正相关。结论青年高血压患者已存在随意注意功能损害;可采用P300评估其认知功能。

Objective To investigate the effects of young patients with hypertension on visual voluntary attention.Methods Using P300 component of the even-related potentials(ERP)to value visual voluntary attention of 24 young patients with essential hypertension and 23 normotensives.Results Compared with control group,visual P300 amplitude in hypertension group was significantly declined(F=4.73,P<0.05),particularly at Pz sites(P<0.05).the latency of visual P300 of hypertension patients(401.31±6.27)ms was different from normal controls(391.34±6.13)ms,but there was no statistical significance(P>0.05).Besides,The amplitude of visual P300 was positively correlated with MMSE scores(r=0.61,P<0.05).Conclusion The ability of visual voluntary attention declined in young hypertension patients.Visual P300 can help evaluate their cognitive function of the young hypertension patients.