小细胞肺癌患者预后与血清SF、ESR及红细胞平均指数水平的相关性分析

Correlation between serum SF,ESR and average red blood cell index levels and the prognosis of patients with small cell lung cancer

目的探讨小细胞肺癌患者预后与血清SF、ESR及红细胞平均指数水平的相关性。方法选择2018年3月至2019年3月本院接收的小细胞肺癌(Small cell lung cancer,SCLC)患者86例为研究对象,患者出院后进行为期1年的跟踪随访,1年内未复发患者41例纳入未复发组;1年内复发患者45例纳入复发组,所有患者均行血清铁蛋白(SF)、红细胞沉降率(ESR)及红细胞平均指数水平[平均红细胞体积(MCV)、平均红细胞血红蛋白含量(MCH)、平均红细胞血红蛋白浓度(MCHC)]检测,分析上述指标与SCLC患者预后的相关性。结果复发组血清SF、ESR、MCV、MCH水平高于未复发组,MCHC水平低于未复发组,差异有统计学意义(P<0.05);经Logistic回归分析结果显示,血清SF、ESR、MCV、MCH水平高表达可能是诱发小细胞肺癌患者复发的影响因素(OR>1,P<0.05)。结论血清SF、ESR及红细胞平均指数水平(MCV、MCH)与SCLC患者预后密切相关,可作为临床早期评估SCLC患者预后有效指标,为病情评估提供靶向依据。

Objective To investigate the correlation between serum SF,ESR and average red blood cell index levels and the prognosis of patients with small cell lung cancer.Methods A total of 86 small cell lung cancer(SCLC)patients treated in our hospital from March 2018 to March 2019 were selected as the research objects.After 1-year follow-up,the patients(n=41)without palindromia entered non-relapsed group,and the patients(n=45)with palindromia entered relapsed group.All patients were tested for serum ferritin(SF),erythrocyte sedimentation rate(ESR)and average red blood cell index level[mean red blood cell volume(MCV),average red blood cell hemoglobin content(MCH),average red blood cell hemoglobin concentration(MCHC)],analyzed the correlation between the above indicators and the prognosis of SCLC patients.Results Serum SF,ESR,MCV,and MCH levels in the relapsed group were higher than those in the non-relapsed group,and MCHC levels were lower than those in the non-relapsed group,the difference between the two groups was statistically significant(P<0.05).Logistic regression analysis showed that high levels of serum SF,ESR,MCV,and MCH might be the influencing factors for the recurrence of small cell lung cancer patients(OR>1,P<0.05).Conclusion Serum SF,ESR and mean red blood cell index(MCV,MCH)are closely related to the prognosis of SCLC patients.In the future,it can be used as an effective indicator for early clinical evaluation of the prognosis of SCLC patients and provide a targeted basis for disease evaluation.