含吡硫翁锌、花粉精、醣丁体等成分的毛发洗护品辅助非那雄胺治疗雄激素性秃发效果

Effect of hair care products containing zinc pyrithione,pollen extract,sachitin and other ingredients assisted with finasteride on androgenic alopecia

目的观察含吡硫翁锌、花粉精、醣丁体等成分的毛发洗护品辅助非那雄胺治疗雄激素性秃发的效果。方法2018年6月至2019年2月,北京友谊医院皮肤科就诊的60例男性雄激素性秃发患者,年龄18~40岁(30.85±4.73)岁。分为试验组和对照组两组,每组30例,均观察180 d。两组均口服非那雄胺每天1 mg,试验组用含吡硫翁锌、花粉精、醣丁体等成分的毛发洗护品,对照组用普通洗护品,评估治疗前后患者头皮、毛发改善情况及患者满意度。结果试验组治疗180 d与对照组比较,试验组患者头皮出油、瘙痒、头皮屑改善程度、总体使用感均显著优于对照组,差异有统计学意义(t=2.744、2.574、2.579、2.134,均P<0.05)。试验组治疗180 d毛发密度显著优于对照组,差异有统计学意义(t=2.077,P<0.05)。满意度方面,试验组患者29例对疗效满意,占96.67%;对照组25例,占83.33%,两组比较差异无统计学意义(P>0.05)。60例患者均未见不良反应。结论含吡硫翁锌、花粉精、醣丁体等成分的毛发洗护品辅助非那雄胺能较好地改善雄激素性秃发患者的头皮出油、瘙痒、头皮屑情况,可增加雄激素性秃发患者脱发疗效,耐受性较好。

Objective To observe the effect of hair care products containing zinc pyrithione,pollen extract,sachitin and other ingredients assisted with finasteride in the treatment of androgenic alopecia.Methods From June 2018 to February 2019,60 male androgen alopecia patients aged 18-40(30.85±4.73)years were enrolled in this study.30 cases in each group were treated for 180 days,and finasteride 1 mg/day was taken orally in both groups.In the experimental group,on the basis of finasteride,hair care products containing zinc pyrithione,pollen extract,sachitin and other ingredients were used,while the control group was treated with common care products.The improvement of scalp and hair and the satisfaction of patients were evaluated before and after treatment.Results After 180 days of treatment,the improvement of scalp oil(t=2.744,P<0.05),pruritus(t=2.574,P<0.05),dandruff(t=2.579,P<0.05)and general sense of use(t=2.134,P<0.05)in the experimental group were significantly better than those in the control group(t=2.077,P<0.05).The hair density of the experimental group was significantly better than that of the control group(P<0.05).The patients'satisfaction rates in the experimental group and the control group were 96.67%(29/30)and 83.33%(25/30),respectively;there was no significant difference between the two groups(P>0.05).No adverse reactions were found in all patients.Conclusions Hair care products containing zinc pyrithione,pollen extract,sachitin and other ingredients assisted with finasteride can improve the scalp oil,pruritus and dandruff of patients with androgenic alopecia,and can increase the curative effect of the treatment of alopecia of the patients.