基于影像组学的头颈部鳞状细胞癌研究进展

Advances in head and neck squamous cell cancer research based on radiomics

头颈部鳞状细胞癌是世界上第六大常见恶性肿瘤[1]。尽管近年来头颈部鳞状细胞癌的手术治疗、放疗及化疗等方面取得了很大进展,但该疾病的5年生存率仍很低;而且不同的发病部位5年生存率差异较大,为25%(下咽癌)~60%(喉癌)[2-3]。超过50%的患者在就诊时已处于疾病晚期[3],此时病变累及广泛,只能选择根治性手术、同步放化疗,以及诱导化疗联合手术治疗等综合治疗手段。由于其部位和功能的特殊性,根治性切除手术亦或综合治疗可能导致头颈部功能的损害甚至丧失,如面容损毁,语言、呼吸以及咀嚼、吞咽功能障碍等,严重影响患者的生存质量[4]。

Radiomics refers to extract advanced quantitative features in radiological images in a high-throughput way,to invert the features into extensible data with the help of mathematical algorithms,and to establish descriptive and predictive models of tumors.It has important value in the diagnosis,treatment and prognosis of tumors.As an entirely new field,radiomics becomes the research hotspot of clinical medicine and biomedical engineering because of its objective,holistic,non-invasive characteristics.Head and neck squamous cell cancer is one of the common malignant tumors.Radiomics is gradually applied to the study of head and neck squamous cell cancer.This article reviews the research progress of radiomics and its application in head and neck cancer.