抗菌肽和抗菌蛋白在慢性鼻窦炎中的作用

Antimicrobial peptides and proteins in chronic rhinosinusitis

慢性鼻窦炎(chronic rhinosinusitis,CRS)是临床常见的鼻腔鼻窦慢性炎症性疾病,影响我国2%~8%的人口,带来沉重的经济和社会负担[1]。作为一种异质性疾病,CRS病理生理学的相关分子机制仍未完全阐明。临床上,常根据息肉的伴发与否将CRS分为慢性鼻窦炎伴息肉(chronic rhinosinusitis with nasal polyps,CRSwNP)和慢性鼻窦炎不伴息肉(chronic rhinosinusitis without nasal polyps,CRSsNP)2种表型,前者通常临床症状重,术后复发率高,治疗更为困难[2-3]。

The pathogenesis of chronic rhinosinusitis(CRS)is closely related to the interactions between the environmental stimuli and the innate defense system.A vast of defensive molecules,such as antimicrobial peptides and proteins(AMPs)could be secreted by the airway epithelial cells and submucosal glands.As an essential component of innate immune system,AMPs are associated with multiple airway disease,such as CRS,chronic obstructive pulmonary disease,bronchiectasis,allergic asthma and so on.AMPs are expressed vastly in nasal mucosa and could exert fundamental antibacterial and inflamatory regulative functions.However,the pathophysiological mechanism of AMPs in CRS is still unclear.What’s more,the heterogeneity among studies is relatively high.Thus,the paper was aimed to review the potential function and inflammatory regulation of AMPs in CRS.More rigorous studies with larger samples are needed in the future,to shed light on its possible pathogeneisis mechanisms.