槐生拜尔孔菌(槐耳)的化学成分及其抗肿瘤活性研究进展

Research progress on chemical constituents and anti-tumor effects of Huai’er (Vanderbylia robiniophila)

槐生拜尔孔菌(槐耳)是我国重要的药用真菌之一,其化学成分主要含有多糖类、甾体类和生物碱类。槐耳被广泛应用于乳腺癌、肝癌、肺癌、胃癌等多种恶性肿瘤的辅助治疗,其作用机制包括抑制肿瘤细胞生长与增殖、侵袭与转移、血管新生、诱导肿瘤细胞发生凋亡、提高机体免疫力等。本文对槐耳的化学成分及其抗肿瘤活性研究进展进行了归纳和总结,为这一药用真菌的深入研究和开发利用提供参考。

Vanderbylia robiniophila(Huai’er) is one of the important medicinal fungi in China.Various compounds including polysaccharides,steroids and alkaloids have been isolated from this fungus.Huai’er is widely used in the adjuvant treatment of breast cancer,liver cancer,lung cancer,gastric cancer and other malignant tumors.It was reported that the mechanisms of the anti-neoplasia effect included inhibition of the growth and proliferation of cancer cells,inhibition of the invasion and migration of cancer cells,suppression of angiogenesis,induction of apoptosis of cancer cells and improving immunity,etc.Herein,the chemical constituents and anti-tumor effect of Huai’er are summarized as reference data for development of this medicinal fungus.