靶向血小板与肿瘤细胞相互作用药物的现状和未来

Current status and future of drugs targeting platelets-tumor cells interactions

血小板与肿瘤细胞的相互作用不仅可以促进恶性肿瘤的转移还可以影响恶性肿瘤相关性血栓的形成。当肿瘤细胞进入血液后,会立即激活血小板,使其黏附于肿瘤细胞表面,保护肿瘤细胞免受血流剪切力和机体免疫系统的攻击,从而促进肿瘤转移;同时,血小板的大量黏附也有可能导致血栓的形成。本文运用生物反应信号网络分析(ingenuity pathway analysis,IPA)和文献整合的方法探究了血小板与肿瘤细胞相互作用的机制,以及针对血小板与肿瘤细胞的相互作用治疗恶性肿瘤转移的潜在药物,为今后基于其作用机制来开发靶向血小板与肿瘤细胞相互作用的新药提供了一定的理论依据和临床参考。

The interaction between platelets and tumor cells can not only promote the metastasis of malignant tumors,but also affect the formation of malignant tumor-related thrombus.When tumor cells enter the blood,they will immediately activate platelets to make them adhere to the surface of tumor cells,protecting tumor cells from blood flow shear force and immune system attack,thereby promoting tumor metastasis.At the same time,the massive adhesion of platelets may also lead to the formation of thrombus.In this article,we use the methods of ingenuity pathway analysis and literature integration to explore the mechanism of platelet-tumor cell interaction and potential drugs for the treatment of malignant tumor metastasis based on the platelet-tumor cell interaction.It provides a certain theoretical basis and clinical reference for the future development of new drugs targeting platelettumor cell interaction based on its mechanism of action.