大剂量生长抑素对重症急性胰腺炎患者外周血胃肠激素及炎性因子水平的影响

Effects of High-dose Somatostatin on Levels of Peripheral Blood Gastrointestinal Hormones and Inflammatory Factors in Patients with Severe Acute Pancreatitis(SAP)

目的研究大剂量生长抑素对重症急性胰腺炎(SAP)患者外周血胃肠激素及炎性因子水平的影响。方法选取江苏省泰州市姜堰中医院2017年1月至2020年1月收治的60例SAP患者作为研究对象。使用随机数字表法将其分为研究组(n=30例)与对照组(n=30例),研究组给予大剂量生长抑素(12 mg/d)持续注射,对照组给予常规剂量(6 mg/d)持续注射。比较两组治疗前后胆囊收缩素(CCK)、血清胃泌素(GAS)、胃动素(MTL)变化;比较两组治疗前后C-反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)变化;比较两组治疗后腹内压、肠鸣音消失时间及胃肠减压引流量。结果治疗后研究组CCK、MTL高于对照组(P<0.05),GAS低于对照组(P<0.05);研究组治疗后CRP、TNF-α、IL-8均低于对照组(P<0.05);研究组治疗后腹内压及肠鸣音消失时间均低于对照组(P<0.05),胃肠减压引流量高于对照组(P<0.05)。结论使用大剂量生长抑素治疗SAP可有效改善患者胃肠道功能,缓解炎症反应,并促进患者恢复。

Objective To study the effects of high-dose somatostatin on levels of peripheral blood gastrointestinal hormones and inflammatory factors in patients with Severe Acute Pancreatitis(SAP).Methods 60 SAP patients admitted to Taizhou Jiangyan Hospital of Traditional Chinese Medicine from January 2017 to January 2020 were selected as the research subjects,and they were divided into study group(n=30)and control group(n=30)according to the random number table method.Study group was given high-dose somatostatin(12 mg/d)for continuous injection,and control group was given conventional dose(6 mg/d)for continuous injection.The changes of cholecystokinin(CCK),serum gastrin(GAS)and motilin(MTL)before and after treatment were compared between the two groups.The changes of C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)and interleukin-8(IL-8)were compared between the two groups before and after treatment.The intra-abdominal pressure,disappearance time of bowel sounds and gastrointestinal decompression drainage volume after treatment were compared between the two groups.Results After treatment,CCK and MTL of study group were higher than those of control group(P<0.05)while GAS was lower than that of control group(P<0.05).After treatment,the levels of CRP,TNF-αand IL-8 of study group were lower than those of control group(P<0.05).The intra-abdominal pressure and disappearance time of bowel sounds after treatment in study group were less and shorter than those in control group(P<0.05),and the gastrointestinal decompression drainage volume was higher than that in control group(P<0.05).Conclusion High-dose somatostatin in the treatment of SAP can effectively improve the gastrointestinal function,alleviate inflammatory response and promote the recovery of patients.